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The association was strongest among men and people with poor cardiometabolic health.

The findings show a greater effect with longer treatment, compared with dipeptidyl peptidase-4 inhibitors.

Nighttime light exposure was more strongly linked to AD prevalence than any other disease factor among those younger than 65 years.

The estimated risk difference varied from −2.45 to 0.63 percentage points with SGLT2 versus dulaglutide among older adults.

The findings were seen in a large study of older veterans with diabetes.

Metformin displayed a lowest risk for dementia across diverse antidiabetics, while α-glucosidase inhibitors had the highest risk.

The National Academies of Sciences, Engineering and Medicine analysis noted that women are disproportionately affected by chronic illnesses, including Alzheimer’s disease, depression and osteoporosis.

The reduction in risk was greatest for those with a history of ischemic heart disease or stroke.

Score had strong discriminatory accuracy in U.K. Biobank test sample and Whitehall cohort, with AUCs of 0.80 and 0.77

The risk increased in association with age-related macular degeneration, cataract and diabetes-related eye disease, but not glaucoma.