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CYP2D6-inhibiting antidepressants were linked to worse outcomes than CYP2D6-neutral antidepressants when used with CYP2D6-metabolizing opioids.
During high-concentration capsaicin patch treatment, a significant decrease was seen in average daily morphine equivalent dose.
The findings seen among adults of all ages, especially those aged 85 years or older; the risk was highest in the first 28 days after initiation.