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Individuals who experienced severe initial and first reinfection were older in age and had a higher mortality risk.
The authors say, however, that the risk remained substantial, even among vaccinated persons during the omicron era.
No significant reduction was seen in the risk for symptomatic SARS-CoV-2 infection with postexposure prophylaxis for five or 10 days.
Hospital-onset SARS-CoV-2 remained associated with increased morbidity and mortality during the omicron era.
The findings were seen among older adults in the six months following a COVID-19 hospitalization.