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Researchers examined prospective associations with multiple health outcomes over 18 years for pedestrians and cyclists using data for 82,297 individuals aged 16 to 74 years.
Metformin displayed a lowest risk for dementia across diverse antidiabetics, while α-glucosidase inhibitors had the highest risk.
Excellent tolerability was seen, with no changes in blood pressure, minimal reports of sedation and minimal dissociation.
Potential class-dependent associations may exist, however.