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Hormone therapy was no aid for cardiovascular disease prevention, and calcium/vitamin D supplementation was no aid for universal fracture prevention.
9,000 to 10,500 steps/day was associated with the lowest mortality risk, regardless of sedentary time.
Proportionately lower log odds were seen for heart disease, heart attack, stroke and composite outcome for days of use between zero and 30 a month.
The agency estimates that the new standard will prevent up to 4,500 premature deaths in the first year of full enforcement.
Individuals with elevated C-reactive protein at 1.0 mg/dL and poverty had a greater risk for 15-year all-cause mortality.
The authors say that the findings show gaps between practice and guideline-based care.
Estimates of use increased from 16.6% in low-income countries to 65.0% in high-income countries.
Age-standardized rates for deaths decreased, but all-age disability-adjusted life years increased.