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Comparable results were seen for dementia, vascular dementia, Alzheimer’s disease, and in analyses stratified by dementia polygenic risk score.
Replacing ultraprocessed foods weight in diet with an equivalent proportion of unprocessed or minimally processed foods may lower risk.
A greater risk for dementia was conferred by comorbid nonalcoholic fatty liver disease and heart disease or stroke.
In Mendelian randomization analyses, 25(OH)D was associated with a risk for dementia but not stroke or neuroimaging outcomes.
The association was most significant for those aged 65 years or older with a history of hypothyroidism who received medication.
“Trouble handling money is thought to be one of the early signs of Alzheimer’s disease, and this finding supports that notion.”
A small reduction in the risk for dementia was seen after the first year for people with shingles versus general population comparators.
Medicare spending was higher for adults with a formal clinical diagnosis of dementia versus a positive screening for cognitive impairment.
Lower gray matter volumes in temporal, frontal, other regions were seen in socially isolated individuals.
The authors say it is important to assess gait in dementia risk assessments.