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Potential class-dependent associations may exist, however.
Excellent tolerability was seen, with no changes in blood pressure, minimal reports of sedation and minimal dissociation.
CYP2D6-inhibiting antidepressants were linked to worse outcomes than CYP2D6-neutral antidepressants when used with CYP2D6-metabolizing opioids.
Metformin displayed a lowest risk for dementia across diverse antidiabetics, while α-glucosidase inhibitors had the highest risk.
No significant increase was seen with the use of GLP-1 RAs versus SGLT2is or DPP4is among older Medicare beneficiaries.
R&D has remained relatively stable among large pharma companies despite a 27.3% growth in sales.
ChatGPT deprescribing decisions varied along activities of daily living status, cardiovascular disease history, and medication type
Supply disruptions increased for drugs with and without reports at the start of the COVID-19 pandemic.
The agency, however, noted that officials cannot rule out that “a small risk may exist,” and said it will continue to investigate.
Polypharmacy increased, peaking at 43.0% in 2017 to March 2020; hyperpolypharmacy increased during 1999-2000 to 2007-2008.