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Older adults with Alzheimer’s disease and related dementia have lower rates of home discharge and higher mortality.
Two trials show a lower amyloid plaque burden with gantenerumab versus placebo at 116 weeks.
Lower percentage of patients at clinic self-identified as Black compared with average percentage living in catchment area
Higher pancreatic fat was linked to lower cognition and brain volumes in middle-aged men at high risk for Alzheimer’s disease.
To a lesser extent, engagement in creative artistic activities and passive mental activities were linked to lower dementia risk.
Similar findings were seen in a a subcohort of participants with APOE-ε4 genetic data and in an external validation cohort.
Additionally, participation was tied to greater retention of subsequent fluid intelligence.
A high false-positive rate was seen when used in primary care with a diverse patient population.
An increased risk for Alzheimer’s disease and related dementia was seen in association with higher and lower versus middle quintile of HDL-C.
Objectively assessed VMS (so-called hot flashes), including sleep VMS, are associated with significantly lower amyloid-β42/40.