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An increased risk for Alzheimer’s disease and related dementia was seen in association with higher and lower versus middle quintile of HDL-C.
Objectively assessed VMS (so-called hot flashes), including sleep VMS, are associated with significantly lower amyloid-β42/40.
Additionally, participation was tied to greater retention of subsequent fluid intelligence.
Older adults with Alzheimer’s disease and related dementia have lower rates of home discharge and higher mortality.
Those in the highest quintile of total cholesterol and triglycerides had increased risk for Alzheimer’s disease and Alzheimer’s-related dementias.
A greater effect was seen for patients aged 70 years and older at time of bacillus Calmette-Guerin vaccination.
Higher sleep apnea severity was related to lower medial temporal lobe subregion volumes in amyloid-positive, but not amyloid-negative, individuals.
A genetic predisposition to Alzheimer’s also is linked to an increased risk of focal epilepsy with hippocampal sclerosis.
Allopurinol linked to 13 to 34 percent lower risk for Parkinson disease, Alzheimer disease, ALS
$2.0 to $5.1 billion would include lecanemab and ancillary costs; estimated annual per-patient coinsurance could reach $6,636