Biogen is dropping controversial Alzheimer’s drug Aduhelm
Jan 31, 2024
Biogen said it will shift its focus to a newer Alzheimer’s drug, Leqembi, which it markets in a partnership with Japan-based Eisai. Leqembi received FDA approval last year.
Monoclonal antibodies provide small benefits in Alzheimer’s disease
Jan 26, 2024
Harms include increased risks for amyloid-related imaging abnormalities (ARIA)-edema, ARIA-hemorrhage and symptomatic ARIA-edema.
Study IDs proportion of dementia cases attributable to known risk factors
Jan 19, 2024
The population-attributable fraction for nongenetic risk factors combined is similar for men and women, but it varies across racial and ethnic groups.
Gantenerumab does not slow clinical decline in early Alzheimer’s disease
Nov 16, 2023
Two trials show a lower amyloid plaque burden with gantenerumab versus placebo at 116 weeks.
17 percent of patients seeing neurologist travel long distance
Sep 13, 2023
Factors associated with long-distance travel include low neurologist density, rural setting and visits for ALS and nervous system cancer.
Panel of 48 CSF proteins complements existing Alzheimer’s biomarkers
Sep 07, 2023
The CSF 48 panel plus existing biomarkers significantly improved the diagnostic performance for the outcomes studied.
Racial/ethnic minorities underrepresented in Alzheimer’s neuroimaging research
Jul 28, 2023
Sample diversity has improved recently, with proportion of Blacks increasing from 3.39% in 1994-2017 to 8.29% in 2018-2022.
Solanezumab does not slow cognitive decline in preclinical Alzheimer’s disease
Jul 19, 2023
The mean change in Preclinical Alzheimer Cognitive Composite score not significantly different at 240 weeks with solanezumab or placebo.
Study links greater number of chronic pain sites to risk for dementia
Jul 12, 2023
A greater number of chronic pain sites was linked to an increased incident all-cause dementia and Alzheimer’s disease but not vascular and frontotemporal dementia.
Appendicular lean mass linked to decrease in Alzheimer’s risk
Jul 10, 2023
A higher appendicular lean mass also was associated with increased cognitive performance.