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Inappropriate diagnosis is common, especially in older patients and those with dementia or an altered mental status on presentation.
A high false-positive rate was seen when used in primary care with a diverse patient population.
The population-attributable fraction for nongenetic risk factors combined is similar for men and women, but it varies across racial and ethnic groups.
At 30 days after discharge, the mortality rate was 3.2% and skilled nursing facility use rate was 2.6%.
An increased risk was seen for atrial fibrillation and cerebrovascular disease, among others.
The findings were seen in older hospitalized patients with advanced chronic obstructive pulmonary disease, dementia or kidney failure.