(HealthDay News) — The difference in health-related quality of life is modestly improved and statistically significant for patients aged 60 years or older with an intracapsular hip fracture who receive a cemented versus an uncemented hemiarthroplasty, according to a study published in the Feb. 10 issue of the New England Journal of Medicine.
Miguel A. Fernandez, Ph.D., from the University of Oxford in the United Kingdom, and colleagues conducted a multicenter trial comparing cemented and uncemented hemiarthroplasty in patients aged 60 years or older with an intracapsular hip fracture (610 and 615 patients, respectively). Health-related quality of life measured with the use of utility scores on the EuroQol Group 5-Dimension (EQ-5D) questionnaire at four months after randomization was assessed as the primary outcome.
The researchers found that the mean EQ-5D utility scores were 0.371 and 0.315 for patients assigned to the cemented and uncemented groups, respectively (adjusted difference, 0.055; 95% confidence interval, 0.009 to 0.101; P = 0.02). The between-group difference was similar at one month and four months, but the difference was smaller at 12 months than at four months. Mortality at 12 months was 23.9 and 27.8% in the cemented and uncemented groups, respectively (odds ratio for death, 0.80; 95 percent confidence interval, 0.62 to 1.05). Periprosthetic fractures occurred in 0.5 and 2.1% of the cemented and uncemented group participants, respectively (odds ratio [uncemented versus cemented], 4.37; 95% confidence interval, 1.19 to 24.00).
“Modern cemented hemiarthroplasty for hip fracture, as compared with uncemented hemiarthroplasty, will lead to modestly better health-related quality of life and fewer periprosthetic fractures,” write the authors of an accompanying editorial.
Abstract/Full Text (subscription or payment may be required)
